Endocrine Abstracts

Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It has been defined by an absence of overt Cushing’s syndrome (CS) signs (no skin weakness, muscle atrophy, or osteoporosis) associated with biological hypercortisolism consisting of high urinary free cortisol (UFC) and an absence of negative feedback loop of cortisol on HPA, defined as 8-AM cortisol level >50 n...

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...